tert-Butyl piperazine-1-carboxylate → HCID 11515466, compound

HRID 912796Notes

Reaction equation

HRID 912796 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[N:12]1([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[C:21]([O:20][C:18]([N:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[C:8]([F:11])([F:10])[F:9])[CH2:14][CH2:13]1)=[O:19])([CH3:24])([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 27828164-chloro-3-(trifluoromethyl)pyridine

Product 1

HCID 11515466HCID 11515466, compound

Procedure

The reaction of 4-chloro-3-trifluoromethylpyridine (2.05 g, 9.4 mmol, Matrix Scientific) and tert-butyl 1-piperazinecarboxylate (2.1 g, 11.3 mmol, Aldrich) under the conditions of Example 3a afforded the crude product, which was purified by silica gel column chromatography (60% EtOAc/hexane) to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 332 (M+1).

Workup

  1. customafforded the crude product, which
  2. customwas purified by silica gel column chromatography (60% EtOAc/hexane)

Sources & evidence

ORD record
ord-8ce9c679c3c5459c9b6349c595be58c0
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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