HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-Bromo-2-[4-(5-chloropyrimidin-4-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole | HCID 11594585 | — |
| Reactant | 1-(5-Chloropyrimidin-4-yl)piperazine trifluoroacetic acid salt | HCID 67401799 | — |
| Product | 4-Bromo-2-[4-(5-chloropyrimidin-4-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole | HCID 57835162 | — |
Reaction Steps
The reaction of 1-(5-chloropyrimidin-4-yl)piperazine trifluoroacetic acid salt (0.414 g, 0.97 mmol, Example 33d), 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.29 g, 0.97 mmol, Example 9b) and N,N-diisopropylethylamine (0.5 mL, 2.91 mmol, Aldrich) under the conditions of Example 1d gave the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 461 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-d9ca4badb3ac4d02a7ade8109a283984 |
| Source note | uspto-grants-2011_09 |