HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- → (2-{4-[7-Chloro-5-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl}pyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Benzimidazole, 2,7-dichloro-5-(trifluoromethyl)- | HCID 66937336 | — |
| Reactant | 2-(1-piperazinyl)-3-Pyridinemethanol | HCID 67400406 | — |
| Product | (2-{4-[7-Chloro-5-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl}pyridin-3-yl)methanol | HCID 178519687 | — |
Reaction Steps
The piperazine from step (a) above (97 mg, 0.5 mmol) reacted with 2,4-dichloro-6-trifluoromethyl-1H-benzoimidazole (85 mg, 0.33 mmol, Example 5b) under the conditions of Example 3c to give the title compound as a white solid. M.p. 252° C. MS (ESI, pos. ion) m/z: 412 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-000749bc0bd3437f82d169bf963e39d7 |
| Source note | uspto-grants-2011_09 |