2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178461515, compound

HRID 912837Notes

Reaction equation

HRID 912837 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:20]([F:23])([F:22])[F:21])[CH:9]=[C:10]([C:11]3[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=3)[C:4]=2[N:3]=1.[Br:24][C:25]1[C:26]([N:31]2[CH2:36][CH2:35][NH:34][C@H:33]([CH3:37])[CH2:32]2)=[N:27][CH:28]=[CH:29][CH:30]=1>>[Br:24][C:25]1[C:26]([N:31]2[CH2:36][CH2:35][N:34]([C:2]3[NH:3][C:4]4[C:10]([C:11]5[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=5)=[CH:9][C:8]([C:20]([F:23])([F:22])[F:21])=[CH:7][C:5]=4[N:6]=3)[C@H:33]([CH3:37])[CH2:32]2)=[N:27][CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazoleHCID 11701597HCID 11701597, compound

Product 1

HCID 178461515HCID 178461515, compound

Procedure

2-Chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole (52 mg, 0.15 mmol, Example 51b) reacted with (3R)-1-(3-bromopyridin-2-yl)-3-methylpiperazine (48 mg, 0.2 mmol, Example 43a) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 570 (M+1).

Sources & evidence

ORD record
ord-ece346932724427b90ab2935aea143a8
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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