HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-Chloro-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one | HCID 67399853 | — |
| Product | 1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)- | HCID 178506058 | — |
Reaction Steps
The benzoimidazol-2-one from step (b) above (1.43 g, 6.0 mmol) reacted with POCl3 under the conditions of Example 1c to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 254.9 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-04d448037a564c19a56f40d72a874d35 |
| Source note | uspto-grants-2011_09 |