1-(3,5-Dichloropyridin-2-yl)piperazine → 5-Chloro-2-[4-(3,5-dichloro-pyridin-2-yl)-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole

Participants

Role	Name	HCID	Charge
Reactant	1-(3,5-Dichloropyridin-2-yl)piperazine	HCID 2771431	—
Reactant	1H-Benzimidazole, 2,6-dichloro-5-(trifluoromethyl)-	HCID 178506058	—
Product	5-Chloro-2-[4-(3,5-dichloro-pyridin-2-yl)-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole	HCID 57835186	—

Reaction Steps

2,5-Dichloro-6-(trifluoromethyl)benzoimidazole (255 mg, 1.0 mmol, Example 84c) reacted with 1-(3,5-dichloropyridin-2-yl)piperazine (232 mg, 1.0 mmol, Example 9a) under the conditions of Example 3c to give the title compound as a white solid. M.p. 93.5-196.4° C. MS (ESI, pos. ion) m/z: 452.0, 454.1 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026241B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-790ca3a09e9e4a1fb8cea90b0aad76e3
Source note	uspto-grants-2011_09