Acetic Anhydride → N-[4-Bromo-3-(trifluoromethyl)phenyl]acetamide

HRID 912865Notes

Reaction equation

HRID 912865 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:13](=[O:15])[CH3:14])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 678524-Bromo-3-(trifluoromethyl)aniline

Product 1

HCID 697838N-[4-Bromo-3-(trifluoromethyl)phenyl]acetamide

Procedure

A mixture of 4-bromo-3-(trifluoromethyl)phenylamine (7.2 g, 30 mmol, Aldrich) and acetic anhydride (29 mL) was stirred at room temperature for 16 h. The reaction mixture was evaporated in vacuo to give the title product as a white solid which was used in the next step without additional purification. MS (ESI, pos. ion) m/z: 484.0 (M+1).

Workup

  1. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-14d5a946ccb2446ab97caabaf252475e
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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