HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine, 2,3,5-trichloro- → (3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine, 2,3,5-trichloro- | HCID 27666 | — |
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Product | (3R)-1-(3,5-Dichloro-pyridin-2-yl)-3-methyl-piperazine | HCID 67402021 | — |
Reaction Steps
2,3,5-Trichloro-pyridine (910 mg, 5.0 mmol, Aldrich) and (R)-(−)-2-methyl-piperazine (700 mg, 7.0 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 247 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-625e43495481456aa33676c23731f94d |
| Source note | uspto-grants-2011_09 |