2-Methylpiperazine, (R)- → {5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol

HRID 912917Notes

Reaction equation

HRID 912917 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1Cl.[CH3:11][C@@H:12]1[CH2:17][NH:16][CH2:15][CH2:14][NH:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[N:6][C:7]=1[N:16]1[CH2:15][CH2:14][NH:13][C@H:12]([CH3:11])[CH2:17]1

Participants

3

Reactant 2

HCID 73304342-Methylpiperazine, (R)-HCID 21882961(5,6-Dichloropyridin-3-yl)methanol

Product 1

HCID 11550484{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol

Procedure

A mixture of (5,6-dichloro-pyridin-3-yl)-methanol (356 mg, 2.0 mmol, Aldrich) and (R)-(−)-2-methyl-piperazine (240 mg, 2.4 mmol, Aldrich reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 242 (M+1).

Workup

  1. customreacted under the conditions of Example 3a

Sources & evidence

ORD record
ord-2e895a6e15764461b973f12264ffefb5
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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