{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461535, compound

HRID 912919Notes

Reaction equation

HRID 912919 reaction equation
[Br:1][C:2]1[C:7]2[NH:8][C:9](Cl)=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[Cl:16][C:17]1[CH:18]=[C:19]([CH2:30][OH:31])[CH:20]=[N:21][C:22]=1[N:23]1[CH2:28][CH2:27][NH:26][C@H:25]([CH3:29])[CH2:24]1>O1CCOCC1>[Br:1][C:2]1[C:7]2[NH:8][C:9]([N:26]3[CH2:27][CH2:28][N:23]([C:22]4[N:21]=[CH:20][C:19]([CH2:30][OH:31])=[CH:18][C:17]=4[Cl:16])[CH2:24][C@H:25]3[CH3:29])=[N:10][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1

Participants

4

Reactant 2

HCID 11550484{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanolHCID 178506061HCID 178506061, compound

Product 1

HCID 178461535HCID 178461535, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 7-bromo-2-chloro-5-trifluoromethyl-1H-benzoimidazole (96 mg, 0.32 mmol, Example 6b) and {5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl}-methanol (96 mg, 0.4 mmol, Example 150a) in dioxane (2 mL) reacted under the conditions of Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 506 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-5ce3608cac8548658a28658781be4140
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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