2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 178474701, compound

HRID 912933Notes

Reaction equation

HRID 912933 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=[CH:10][C:4]=2[N:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH2:29][N:30]([CH3:34])[C:31](=[O:33])[CH3:32])[CH:19]=[N:20][C:21]=1[N:22]1[CH2:27][CH2:26][NH:25][C@H:24]([CH3:28])[CH2:23]1>C(O)C>[Cl:15][C:16]1[CH:17]=[C:18]([CH2:29][N:30]([CH3:34])[C:31](=[O:33])[CH3:32])[CH:19]=[N:20][C:21]=1[N:22]1[CH2:27][CH2:26][N:25]([C:2]2[NH:3][C:4]3[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:5]=3[N:6]=2)[C@H:24]([CH3:28])[CH2:23]1

Participants

4

Reactant 2

HCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 67401544N-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide

Product 1

HCID 178474701HCID 178474701, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-chloro-6-trifluoromethyl-1H-benzoimidazole (88 mg, 0.4 mmol, Example 1c) and N-[5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-ylmethyl]-N-methyl-acetamide from step (b) above (148 mg, 0.5 mmol) in ethanol (2 mL) reacted under the conditions Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 481 (M+1).

Workup

  1. customreacted under the conditions Example 3c

Sources & evidence

ORD record
ord-b37abc5ed20b4526a517c691409e8285
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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