4-Chlorophenylboronic acid → HCID 178461530, compound

HRID 912938Notes

Reaction equation

HRID 912938 reaction equation
Br[C:2]1[C:10]2[N:9]=[C:8]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[C:22]([Cl:23])=[CH:21][C:20]([Cl:24])=[CH:19][N:18]=4)[CH2:13][C@H:12]3[CH3:25])[NH:7][C:6]=2[CH:5]=[C:4]([C:26]([F:29])([F:28])[F:27])[CH:3]=1.[Cl:30][C:31]1[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=1>>[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([C:2]2[C:10]3[NH:9][C:8]([N:11]4[CH2:16][CH2:15][N:14]([C:17]5[C:22]([Cl:23])=[CH:21][C:20]([Cl:24])=[CH:19][N:18]=5)[CH2:13][C@H:12]4[CH3:25])=[N:7][C:6]=3[CH:5]=[C:4]([C:26]([F:27])([F:29])[F:28])[CH:3]=2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 578351914-bromo-2-[(2R)-4-(3,5-dichloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole

Product 1

HCID 178461530HCID 178461530, compound

Procedure

4-Bromo-2-[(2R)-4-(3,5-dichloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole (204 mg, 0.4 mmol, Example 149b) and 4-chlorophenylboronic acid (124 mg, 0.8 mmol, Aldrich) reacted under the conditions of Example 158 to give the title compound. MS (ESI, pos. ion) m/z: 504 (M+1).

Sources & evidence

ORD record
ord-3ce56fbfc1d342a79bb36ea26e8fb2bd
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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