HuagongsheHuagongshe Chemistry Print Report · For research reference only
{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461549, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol | HCID 11550484 | — |
| Reactant | 2-chloro-4-nitro-6-(trifluoromethyl)-1H-benzoimidazole | HCID 11637534 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178461549 | HCID 178461549 | — |
Reaction Steps
A mixture of {5-chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl}-methanol (1.21 g, 5.0 mmol, Example 150a) and 2-chloro-7-nitro-5-trifluoromethyl-1H-benzoimidazole (1.33 g, 5.0 mmol, Example 57c) in EtOH (4 mL) reacted under the conditions of Example 3c to give the title compound as a yellow solid. MS (ESI, pos. ion) m/e: 471 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e6ab9a15246f4303909510135f6baea2 |
| Source note | uspto-grants-2011_09 |