反应详情

5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-nicotinic acid methyl ester from step (b) above (271 mg, 1.0 mmol) and 2-chloro-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (350 mg, 1.0 mmol, Example 51b) reacted under the conditions of Example 3c to give the title compound as a white solid. MS ESI, pos. ion) m/e: 584 (M+1).