2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole → HCID 178498831, compound

HRID 912959Notes

Reaction equation

HRID 912959 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([N:11]2[CH2:16][CH2:15][NH:14][C@H:13]([CH3:17])[CH2:12]2)=[N:6][CH:5]=1.Cl[C:20]1[NH:24][C:23]2[CH:25]=[C:26]([C:38]([F:41])([F:40])[F:39])[CH:27]=[C:28]([C:29]3[CH:34]=[C:33]([F:35])[C:32]([F:36])=[C:31]([F:37])[CH:30]=3)[C:22]=2[N:21]=1>>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[C:8]([Cl:10])[C:7]([N:11]2[CH2:16][CH2:15][N:14]([C:20]3[NH:21][C:22]4[C:28]([C:29]5[CH:30]=[C:31]([F:37])[C:32]([F:36])=[C:33]([F:35])[CH:34]=5)=[CH:27][C:26]([C:38]([F:41])([F:39])[F:40])=[CH:25][C:23]=4[N:24]=3)[C@H:13]([CH3:17])[CH2:12]2)=[N:6][CH:5]=1

Participants

3

Reactant 2

HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazoleHCID 11666200HCID 11666200, compound

Product 1

HCID 178498831HCID 178498831, compound

Procedure

5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-nicotinic acid methyl ester from step (b) above (271 mg, 1.0 mmol) and 2-chloro-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole (350 mg, 1.0 mmol, Example 51b) reacted under the conditions of Example 3c to give the title compound as a white solid. MS ESI, pos. ion) m/e: 584 (M+1).

Sources & evidence

ORD record
ord-f4bc8a875d1a4b8d81e484e512ebc51f
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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