4-(Trifluoromethyl)phenylboronic acid → HCID 86593836, compound

HRID 912970Notes

Reaction equation

HRID 912970 reaction equation
Br[C:2]1[C:10]2[NH:9][C:8](=[O:11])[NH:7][C:6]=2[CH:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[CH:3]=1.[F:16][C:17]([F:28])([F:27])[C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[F:13][C:12]([F:15])([F:14])[C:4]1[CH:3]=[C:2]([C:21]2[CH:22]=[CH:23][C:18]([C:17]([F:28])([F:27])[F:16])=[CH:19][CH:20]=2)[C:10]2[NH:9][C:8](=[O:11])[NH:7][C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 115800214-Bromo-6-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one

Product 1

HCID 86593836HCID 86593836, compound

Procedure

4-Bromo-6-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one 562 mg, 2.0 mmol, Example 6a) reacted with 4-trifluoromethylphenylboronic acid (760 mg, 4.0 mmol, Aldrich) under the conditions of Example 10 to give the title compound as a white solid. MS (ESI, neg. ion) m/z: 345 (M−1).

Sources & evidence

ORD record
ord-3eba88b57e544b4d8b07cdf7f27a48a3
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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