HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Hydroxymethyl-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester → (6-Piperazin-1-yl-5-trifluoromethyl-pyridin-3-yl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Hydroxymethyl-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 67401213 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (6-Piperazin-1-yl-5-trifluoromethyl-pyridin-3-yl)-methanol | HCID 67401808 | — |
Reaction Steps
4-(5-Hydroxymethyl-3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester from step (d) above (1.08 g, 3.0 mmol) reacted with TFA (10 mL, Aldrich) under the conditions of Example 183 g to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 262 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-9ffbf3feedb04f20b600c609e951fa9b |
| Source note | uspto-grants-2011_09 |