4-(Trifluoromethyl)phenylboronic acid → 2-[(2R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-5-trifluoromethyl-7-(4-trifluoromethyl-phenyl)-1H-benzoimidazole

Participants

Role	Name	HCID	Charge
Reactant	4-(Trifluoromethyl)phenylboronic acid	HCID 2734389	—
Reactant	HCID 178461521	HCID 178461521	—
Product	2-[(2R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-5-trifluoromethyl-7-(4-trifluoromethyl-phenyl)-1H-benzoimidazole	HCID 178461523	—

Reaction Steps

7-Bromo-2-[(2R)-4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl]-5-(trifluoromethyl)-1H-benzoimidazole (95 mg, 0.2 mmol, Example 77) and 4-(trifluoromethyl)phenylboronic acid (47 mg, 0.25 mmol, Aldrich) reacted under the conditions of Example 51a to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 515 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08026241B2
Source dataset	uspto-grants-2011_09
ORD ID	ord-a002c45edc5041e3a68276e66e2fbfee
Source note	uspto-grants-2011_09