HCID 15629469, compound → HCID 22660847, compound

HRID 913046Notes

Reaction equation

HRID 913046 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6](Cl)([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Cu](C#N)[C:23]#[N:24]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]([C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:23]#[N:24])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 15629469HCID 15629469, compoundHCID 178418260HCID 178418260, compound

Product 1

HCID 22660847HCID 22660847, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
150 °C

Procedure

2-(4-Chlorophenyl) 2,2-diphenylacetonitrile was synthesized by carefully triturating 1.50 g (4.8 mmol) of 4-chlorotrityl chloride with 1.00 g (11 mmol) of copper cyanide and the resulting mixture was heated for 4 hours at 150° C. without a solvent. After cooling 50 ml of toluene was added, the mixture was filtered and the filtrate was concentrated in vacuo. The resulting residue was recrystallized from petroleum ether (40-60° C.) to give 0.66 g (45%) of the triarylmethyl acetonitrile derivative.

Workup

  1. additionwas added
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate was concentrated in vacuo
  4. customThe resulting residue was recrystallized from petroleum ether (40-60° C.)

Sources & evidence

ORD record
ord-df967add46e444088b55a087de446962
Source dataset
uspto-grants-2011_09
Patent number
US08026263B2

Reaction notes

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