Trifluoroacetic acid methylene chloride → HCID 67382333, compound

Participants

Reaction Steps

The alcohol C1 was dissolved in DCM/TFA (8:2, 0.03 M solution) and the solution was stirred for 2 hr and then the solvents were removed under reduced pressure and the crude was purified by preparative RP-HPLC (column: C18), using H2O (0.1% TFA) and MeCN (+0.1% TFA) as eluents. The desired fractions were lyophilized to yield a white powder. 1H NMR (400 MHz, DMSO-d6) δ: 14.41 (1H, bs), 8.40 (1H, s), 8.22 (1H, s), 8.15-8.06 (1H, m), 8.03-7.92 (3H, m), 7.70-7.54 (2H, m), 3.70 (2H, d, J=5.9 Hz), 3.32-3.19 (1H, m), 2.47-2.32 (4H, m), 1.88-1.72 (2H, m), 1.56-1.40 (2H, m), 1.35-1.15 (4H, m), 0.92 (3H, t, J=7.2 Hz). MS (ES) C23H28N2O2 requires: 364, found: 365 (M+H)+.

Provenance & Evidence