3,5-Diisopropoxybenzaldehyde → HCID 67399961, compound

HRID 913132Notes

Reaction equation

HRID 913132 reaction equation
C(OC1C=C(C=CC=1C)CN1CCC(NC2C=C(C=CN=2)C#N)CC1)C.Cl.Cl.[NH:29]1[CH2:34][CH2:33][CH:32]([NH:35][C:36]2[CH:37]=[C:38]([CH:41]=[CH:42][N:43]=2)[C:39]#[N:40])[CH2:31][CH2:30]1.[CH:44]([O:47][C:48]1[CH:49]=[C:50]([CH:53]=[C:54]([O:56][CH:57]([CH3:59])[CH3:58])[CH:55]=1)[CH:51]=O)([CH3:46])[CH3:45]>>[CH:57]([O:56][C:54]1[CH:53]=[C:50]([CH:49]=[C:48]([O:47][CH:44]([CH3:46])[CH3:45])[CH:55]=1)[CH2:51][N:29]1[CH2:30][CH2:31][CH:32]([NH:35][C:36]2[CH:37]=[C:38]([CH:41]=[CH:42][N:43]=2)[C:39]#[N:40])[CH2:33][CH2:34]1)([CH3:58])[CH3:59]

Participants

4

Reactant 3

HCID 113106053,5-Diisopropoxybenzaldehyde2×HCID 67398466HCID 67398466, compoundHCID 67401550HCID 67401550, compound

Product 1

HCID 67399961HCID 67399961, compound

Procedure

The title compound was prepared in analogy to the synthesis of 2-[1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-ylamino]-isonicotinonitrile (example 189) from 2-(piperidin-4-ylamino)-isonicotinonitrile dihydrochloride (intermediate B15) and 3,5-diisopropoxy-benzaldehyde (intermediate E4) in a yield of 3.6 mg (5%). MS (ISP): 409.5 [M+H]+.

Sources & evidence

ORD record
ord-32a4cea0193f4dd3bf14b49d086720c1
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

Loading…