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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 913139생성일: 2026년 10월 25일

3-Ethoxy-4-methoxybenzaldehyde → 6-[1-(3-Ethoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid

https://huagongshe.com/reaction/913139

반응식

참여 물질

역할이름HCID투입량
반응물3-Ethoxy-4-methoxybenzaldehydeHCID 244728—
반응물6-(Piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochlorideHCID 42604213—
반응물6-[1-(3-Ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acidHCID 67401086—
생성물6-[1-(3-Ethoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acidHCID 67398939—

반응 단계

The title compound was prepared in analogy to the synthesis of 6-[1-(3-ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid (example 201) from 6-(piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride (intermediate B7) and 3-ethoxy-4-methoxy-benzaldehyde (commercially available) in a yield of 15.3 mg (22%). MS (ISP): 454.2 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08026255B2
출처 데이터셋uspto-grants-2011_09
ORD IDord-87f6ddea400545a097b4d23d30fe20e4
출처 메모uspto-grants-2011_09