HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methoxy-3-(2-methylpropoxy)benzaldehyde → 6-[1-(3-Isobutoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methoxy-3-(2-methylpropoxy)benzaldehyde | HCID 2414110 | — |
| Reactant | 6-(Piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride | HCID 42604213 | — |
| Reactant | 6-[1-(3-Ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid | HCID 67401086 | — |
| Product | 6-[1-(3-Isobutoxy-4-methoxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid | HCID 67399976 | — |
Reaction Steps
The title compound was prepared in analogy to the synthesis of 6-[1-(3-ethoxy-4-hydroxy-benzyl)-piperidin-4-ylamino]-4-trifluoromethyl-nicotinic acid (example 201) from 6-(piperidin-4-ylamino)-4-trifluoromethyl-nicotinic acid methyl ester dihydrochloride (intermediate B7) and 3-isobutoxy-4-methoxy-benzaldehyde (intermediate E12) in a yield of 9.0 mg (12%). MS (ISP): 482.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026255B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-14de9fdae25f4b99b437670a8adb8877 |
| Source note | uspto-grants-2011_09 |