HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-{3-[1-(4-Chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-phenyl}-acetamide → 5-[1-(2,6-Diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-ylamino]-pyrazine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-{3-[1-(4-Chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-phenyl}-acetamide | HCID 24854968 | — |
| Reactant | 2,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde | HCID 59383100 | — |
| Reactant | 5-(Piperidin-4-ylamino)-pyrazine-2-carboxylic acid methyl ester dihydrochloride | HCID 67399609 | — |
| Product | 5-[1-(2,6-Diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-ylamino]-pyrazine-2-carboxylic acid methyl ester | HCID 67400938 | — |
Reaction Steps
The title compound was prepared in analogy to the synthesis of 6-[1-(3-ethoxy-4-methyl-benzyl)-piperidin-4-ylamino]-nicotinonitrile (example 38/step 3) from 5-(piperidin-4-ylamino)-pyrazine-2-carboxylic acid methyl ester dihydrochloride (intermediate B14) and 2,6-diethoxy-4′-fluoro-biphenyl-4-carbaldehyde (intermediate E22) in a yield of 5.8 mg (7%). MS (ISP): 509.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026255B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-1d9d7d021e9445be9f9e636f6048250a |
| Source note | uspto-grants-2011_09 |