HCID 86618563, compound → HCID 86618565, compound

HRID 913161Notes

Reaction equation

HRID 913161 reaction equation
ClC1C=C(C=C(NC2CCN(CC3C=C(OCC)C(Cl)=C(OCC)C=3)CC2)N=1)C(O)=O.C[O:33][C:34](=[O:69])[C:35]1[CH:40]=[C:39]([NH:41][CH:42]2[CH2:47][CH2:46][N:45]([CH2:48][C:49]3[CH:54]=[C:53]([O:55][CH2:56][CH3:57])[C:52]([C:58]4[CH:63]=[CH:62][C:61]([F:64])=[CH:60][CH:59]=4)=[C:51]([O:65][CH2:66][CH3:67])[CH:50]=3)[CH2:44][CH2:43]2)[N:38]=[C:37]([Cl:68])[CH:36]=1>>[Cl:68][C:37]1[CH:36]=[C:35]([CH:40]=[C:39]([NH:41][CH:42]2[CH2:47][CH2:46][N:45]([CH2:48][C:49]3[CH:54]=[C:53]([O:55][CH2:56][CH3:57])[C:52]([C:58]4[CH:59]=[CH:60][C:61]([F:64])=[CH:62][CH:63]=4)=[C:51]([O:65][CH2:66][CH3:67])[CH:50]=3)[CH2:44][CH2:43]2)[N:38]=1)[C:34]([OH:69])=[O:33]

Participants

3

Reactant 2

HCID 86618563HCID 86618563, compoundHCID 86618566HCID 86618566, compound

Product 1

HCID 86618565HCID 86618565, compound

Procedure

The title compound was prepared in analogy to the procedure described for 2-chloro-6-[1-(4-chloro-3,5-diethoxy-benzyl)-piperidin-4-ylamino]-isonicotinic acid (example 232) from 2-chloro-6-[1-(2,6-diethoxy-4′-fluoro-biphenyl-4-ylmethyl)-piperidin-4-ylamino]-isonicotinic acid methyl ester (example 225) and obtained as colorless solid. MS (ISN): 526.1 [M−H]−.

Workup

  1. customobtained as colorless solid

Sources & evidence

ORD record
ord-cd889346c07b45d48401c9f6fcb32f53
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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