Acetic Acid → (3-Chloro-4-{1,3-dioxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetic acid

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Reaction Steps

Ethyl (3-chloro-4-{1,3-dioxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate (0.375 g, 0.64 mmol) was heated to 100° C. in a 1:1 mixture of acetic acid:2N aqueous hydrochloric acid (20 ml) for 5 hours. The reaction was cooled to room temperature. On addition of water, the resulting white solid was collected by filtration and washed with water (0.315 g, 0.56 mmol). LC/MS: Rt=3.57, [MH]+ 562.

Provenance & Evidence