Triethylsilane → (3-chloro-4-{1-oxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetic acid

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Reaction Steps

To a solution of (3-chloro-4-{1-hydroxy-3-oxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetic acid (0.235 g, 0.42 mmol) in trifluoroacetic acid (5 ml) cooled to 0° C., was added triethylsilane (0.10 ml, 0.63 mmol). Stirring continued at 0° C. for 5 minutes and then the mixture was evaporated. The crude mixture was purified using MDAP. The clean fractions were evaporated to give a white solid. This was triturated with ether, the resulting white solid collected by filtration (0.008 g, 0.015 mmol). LC/MS: Rt=3.49, [MH]+548.

Provenance & Evidence