反应详情

A mixture of diethyl 1-(ethyloxy)-4-[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylate (3.05 g, 7.23 mmol), ethanol (30 ml), and 2N aqueous sodium hydroxide solution (35 ml) was refluxed for 3 hours. The reaction mixture was cooled and evaporated. This was acidified with HCl (2N) and extracted with 2× ethyl acetate. Combined organics were dried over magnesium sulphate and the solvent evaporated to give the title compound as a white solid (2.55 g, 6.97 mmol). LC/MS: Rt=2.76, [MH]− 365.

1. temperaturewas refluxed for 3 hours
2. temperatureThe reaction mixture was cooled
3. customevaporated
4. extractionextracted with 2× ethyl acetate
5. dry with materialCombined organics were dried over magnesium sulphate
6. customthe solvent evaporated