反应详情

10% Palladium on carbon (0.175 g) was suspended in ethanol (150 ml), to this was added ethyl (4-{4-(ethyloxy)-1,3-dioxo-9-[(phenylmethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-fluorophenyl)acetate (1.75 g, 3.32 mmol). The reaction was stirred at room temperature under an atmosphere of hydrogen for 3 hours. This was filtered through a bed of celite under a blanket of argon, and washed with dichloromethane. The filtrate was evaporated to give a yellow solid (1.56 g, 3.57 mmol). LC/MS: Rt=3.50, [MH]+ 438.

1. filtrationThis was filtered through a bed of celite under a blanket of argon
2. washwashed with dichloromethane
3. customThe filtrate was evaporated