Acetic Acid → (4-{4-(Ethyloxy)-1,3-dioxo-9-[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-fluorophenyl)acetic acid

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Reaction Steps

Ethyl (4-{4-(ethyloxy)-1,3-dioxo-9-[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}-3-fluorophenyl)acetate (0.119 g, 0.23 mmol) was heated to 100° C. in a 1:1 mixture of acetic acid:2N aqueous hydrochloric acid (10 ml) for 2 hours. On addition of water, the resulting cream solid was collected by filtration and washed with water. This was purified by MDAP to give the title compound as a white solid (0.073 g, 0.15 mmol). LC/MS: Rt=3.38, [MH]+ 492.

Provenance & Evidence