Sodium Hydroxide → HCID 24760119, compound

Participants

Reaction Steps

Ethyl (3-chloro-4-{4-(ethyloxy)-1-oxo-9-[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate (0.041 g, 0.08 mmol) was heated to reflux in a 1:1 mixture of 2N sodium hydroxide:ethanol (10 ml) for 1 hour. The reaction was cooled to room temperature. The ethanol was evaporated and the mixture acidified with HCl (2N). The resulting white solid was collected by filtration, washed with water and dried under vacuum. This was purified by MDAP to give the title compound (0.014 g, 0.03 mmol) as a clear foam. LC/MS: Rt=3.42, [MH]+ 494.

Provenance & Evidence