Methanol → Methyl 5-phenylpentanoate

HRID 913228Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:14]O>>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 887Methanol

HCID 16757Benzenepentanoic acid

Product 1

HCID 262942Methyl 5-phenylpentanoate

Procedure

5-Phenylpentanoic acid (10.0 g) was dissolved in 250 mL of methanol and sparged with hydrogen chloride gas at room temperature for 15 minutes. The solvent was then removed under vacuum. Methyl 5-phenylpentanoate obtained was used in the next step without further purification.

Workup

customsparged with hydrogen chloride gas at room temperature for 15 minutes
customThe solvent was then removed under vacuum

Sources & evidence

ORD record: ord-2a81acb623ca4142a41d1a84e27f9511
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08026280B2

Reaction notes

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