HCID 86636502, compound → HCID 57971494, compound

Participants

Reaction Steps

A solution of benzyl {4-[({4-[(tert-butoxycarbonyl)amino]-1-phenyl-1H-pyrazol-3-yl}amino)carbonyl]benzyl}carbamate (0.75 g, 1.38 mmol) in methanol (150 mL) was treated with palladium hydroxide on carbon (75 mg) and placed under a hydrogen atmosphere for 1.5 hours. The reaction was filtered, evaporated in vacuo and purified by flash column chromatography (1-18% methanol/methylene chloride) to give title compound as an off-white solid. 1H NMR (DMSO-d6) δ 8.37 (s, 1H), 7.99 (d, J=8.2 Hz, 2H), 7.71 (d, J=7.9 Hz, 2H), 7.50 (d, J=8.2 Hz, 2H), 7.45 (t, J=7.6 Hz, 2H), 7.27 (t, J=7.3 Hz, 1H), 3.90 (s, 2H), 1.50 (s, 9H); ESIMS calcd 408.2 (M++H), found 408.1 (M++H).

Provenance & Evidence