N-Methylbenzeneethanamine → HCID 67408155, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-bromo-1,3-thiazole-5-carboxylate (0.5 g, 2.1 mmol) in THF (2 mL) was added N-methylphenethylamine (0.86 g, 6.4 mmol). The reaction was heated to 100° C. via microwave for 30 minutes. The reaction was partitioned between water and ethyl acetate. The organics were dried over sodium sulfate, filtered and evaporated. Purification by flash chromatography (15-50% ethyl acetate/hexanes) gave ethyl 2-[methyl(2-phenylethyl)amino]-1,3-thiazole-5-carboxylate. 1H NMR (600 MHz, DMSO-d6) δ 7.81 (s, 1H), 7.22 (m, 5H), 4.17 (q, J=7.34 Hz, 2H), 3.70 (t, J=7.33 Hz, 2H), 3.00 (s, 3H), 2.87 (t, J=7.63 Hz, 2H), 1.21 (t, J=7.01 Hz, 3H); ESIMS calcd 291.1 (M++H), found 291.0 (M++F).

Provenance & Evidence