Lithium Hydroxide → HCID 57971491, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 2-[methyl(2-phenylethyl)amino]-1,3-thiazole-5-carboxylate (0.56 g, 1.93 mmol) in dioxane (10 mL) was added lithium hydroxide (5.8 mmol, 1.9 mL of a 3.0M solution) and the reaction was warmed to 75° C. for 2.5 hours. The reaction was partitioned between 1M HCl and ethyl acetate. The organics were dried over sodium sulfate, filtered and evaporated to give the title compound. 1H NMR (600 MHz, DMSO-d6) δ 7.73 (s, 1H), 7.22 (m, 5H), 3.68 (t, J=7.33 Hz, 2H), 3.31 (bs, 1H), 2.99 (s, 3H), 2.87 (t, J=7.63 Hz, 2H); ESIMS calcd 263.1 (M++H), found 263.0 (M++H).

Provenance & Evidence