HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-[1-(1,3-Benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-[1-(1,3-benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoate | HCID 67405959 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[1-(1,3-Benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoic acid | HCID 57971508 | — |
Reaction Steps
To a solution of tert-butyl 4-[1-(1,3-benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoate (90 mg, 0.25 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (0.5 mL) and the solution was stirred at ambient temperature for 1 hour. The reaction was evaporated to dryness to give the title compound as a clear oil. ESIMS calcd 312.1 (M++H), found 312.0 (M++M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026260B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-ba58bbf42c214e2b8ef3a66f23e4892d |
| Source note | uspto-grants-2011_09 |