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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913244Generated: October 31, 2026

Trifluoroacetic acid → 4-[1-(1,3-Benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoic acid

https://huagongshe.com/reaction/913244

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTert-butyl 4-[1-(1,3-benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoateHCID 67405959—
SolventDichloromethaneHCID 6344—
Product4-[1-(1,3-Benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoic acidHCID 57971508—

Reaction Steps

To a solution of tert-butyl 4-[1-(1,3-benzoxazol-2-yl)-2-methoxy-2-oxoethyl]benzoate (90 mg, 0.25 mmol) in methylene chloride (2 mL) was added trifluoroacetic acid (0.5 mL) and the solution was stirred at ambient temperature for 1 hour. The reaction was evaporated to dryness to give the title compound as a clear oil. ESIMS calcd 312.1 (M++H), found 312.0 (M++M).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026260B2
Source datasetuspto-grants-2011_09
ORD IDord-ba58bbf42c214e2b8ef3a66f23e4892d
Source noteuspto-grants-2011_09