Water → HCID 16212620, compound

10 g of polyethylene glycol (Mw ˜400, 10.0 g) in acetone (400 mL) was cooled to 15° C. and Jones reagent was added [(43 mL), prepared from 5.18 mL H2SO4, 5 g of CrO3 and 38 mL H2O]. The mixture was stirred at room temperature for 12 h. The acetone was removed under vacuum, the slurry dissolved in CH2Cl2 (150 mL) and washed with saturated NaCl solution (1×100 mL). The CH2Cl2 layer was dried (anhydrous MgSO4) and solvents removed to obtain corresponding poly(ethylene glycol) bis(carboxymethyl) ether (Mw ˜400) as an oil (9.35 g). IR, neat, 1739 cm−1, C═O stretch of carboxylic acid, 3436 cm−1 Broad O′H stretch.

1. customThe acetone was removed under vacuum
2. dissolutionthe slurry dissolved in CH2Cl2 (150 mL)
3. washwashed with saturated NaCl solution (1×100 mL)
4. dry with materialThe CH2Cl2 layer was dried (anhydrous MgSO4) and solvents
5. customremoved

ORD record

ord-079f7cd870ca4a91a6ab3b5c4493dac5

Source dataset

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08026289B2