Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Stavudine | HCID 18283 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Stavudine DMPU | HCID 86625622 | 87.5% |
Reaction Steps
Crude Stavudine (25 g, 97.7% pure, 0.1116 mole), DMPU (37.5 g, 1.5 parts) are added to acetone (50 ml) and heated to 56° C. for dissolution. The obtained solution is stirred for 15 min. at 56° C. and cooled to 6-8° C. The precipitated product is filtered, washed with acetone and dried to give 34.4 g of Stavudine DMPU solvate (87.5%) with a chromatographic purity 99.93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08026356B2 |
|---|
| Source dataset | uspto-grants-2011_09 |
|---|
| ORD ID | ord-2bdc41f217664607a37266af142ffb4a |
|---|
| Source note | uspto-grants-2011_09 |
|---|
