3-Chloroaniline → HCID 67389780, compound

Participants

Reaction Steps

To a solution of 2-chloro-4-(2-chloro-4-pyrimidinyl)-1,3,5-triazine (i.e., the product of Example 1, Step B) (25 mg, 0.11 mmol) in tetrahydrofuran (1.0 mL) was added 3-chloroaniline (0.1 mL), and the resulting mixture was stirred at room temperature for 3 h to provide a yellow suspension. To this suspension added 4-aminotetrahydropyran (0.2 mL), and the mixture was refluxed for 5 h. The solution was concentrated and purified using column chromatography on silica gel eluted with 70% ethyl acetate in hexanes to give 25 mg of the title compound as a yellow solid.

Provenance & Evidence