5-Aminopyridine-2-carbonitrile → HCID 67390012, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-4-(2-chloro-4-pyrimidinyl)-1,3,5-triazine (i.e., the product of Example 1, Step B) (100 mg, 0.43 mmol) in tetrahydrofuran (2.0 mL) was added 5-amino-2-pyridinecarbonitrile (86 mg, 0.72 mmol), and the resulting mixture was stirred at 40° C. for 3 h. To this mixture was added (S)-1-methoxy-2-propylamine (0.2 mL), and the resulting mixture was refluxed for 2 h. The solution was concentrated and purified using column chromatography on silica gel eluted with a gradient of 70% to 80% ethyl acetate in hexanes to give 84 mg of the title compound as a yellow solid.

Provenance & Evidence