3-Fluoro-5-nitroaniline → HCID 67389955, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-chloro-4-(2-chloro-4-pyrimidinyl)-1,3,5-triazine (i.e., the product of Example 1, Step B) (68 mg, 0.30 mmol) in tetrahydrofuran (2.0 mL) was added 3-fluoro-5-nitroaniline (72 mg, 0.46 mmol), and the resulting mixture was stirred at 50° C. for 1 h to form a yellow suspension. To this suspension was added (S)-1-methoxy-2-propylamine (0.2 mL), and the resulting mixture was refluxed for 3 h. The solution was concentrated and purified using column chromatography on silica gel eluted with 70% ethyl acetate in hexanes to give 93 mg of the title compound as yellow solid.

Provenance & Evidence