3-Fluoroaniline → N-cyclopentyl-4-[2-[(3-fluorophenyl)amino]-4-pyridinyl]-2-pyrimidinamine

HRID 913292Notes

Reaction equation

HRID 913292 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.[F:20][C:21]1[CH:22]=[C:23]([CH:25]=[CH:26][CH:27]=1)[NH2:24]>>[CH:15]1([NH:14][C:10]2[N:9]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[C:21]([F:20])[CH:22]=4)[CH:7]=3)[CH:13]=[CH:12][N:11]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 97423-FluoroanilineHCID 866467774-(2-chloro-4-pyridinyl)-N-cyclopentyl-2-pyrimidinamine2×

Product 1

HCID 67389596N-cyclopentyl-4-[2-[(3-fluorophenyl)amino]-4-pyridinyl]-2-pyrimidinamine

Procedure

The title compound was prepared in the same fashion as described in Example 7, Step D using 4-(2-chloro-4-pyridinyl)-N-cyclopentyl-2-pyrimidinamine (i.e., the product of Step A) and 3-fluoroaniline.

Sources & evidence

ORD record
ord-c842e093bb89462ebad84b41a514101e
Source dataset
uspto-grants-2011_09
Patent number
US08026359B2

Reaction notes

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