Hydrochloric Acid → N-(4-Cyano-piperidin-4-yl)-5-methyl-nicotinamide dihydrochloride

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Reaction Steps

A solution of 4-cyano-4-[(5-methyl-pyridine-3-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (0.48 g, 1.39 mmol) in 4 M HCl in dioxane (7 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. Note: The product is contaminated with some primary amide (partial hydrolysis of the nitrile). MS (ISP): 245.4 [M+H]+.

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