4-[(6-Chloro-pyridine-3-carbonyl)-amino]-4-cyano-piperidine-1-carboxylic acid tert-butyl ester → 6-Chloro-N-(4-cyano-piperidin-4-yl)-nicotinamide dihydrochloride

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Reaction Steps

A solution of 4-[(6-chloro-pyridine-3-carbonyl)-amino]-4-cyano-piperidine-1-carboxylic acid tert-butyl ester (0.30 g, 0.82 mmol) in 4 M HCl in dioxane (4 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. Note: The product is contaminated with some primary amide (partial hydrolysis of the nitrile). MS (ISP): 265.3 [M+H]+.

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