Hydrazine hydrate (1:1) → 5-hydrazinocarbonylthiophene-2-carboxylic Acid 2-propylamide

Participants

Reaction Steps

Methyl 5-(2-propylcarbamyl)-thiophene-2-carboxylate (1.22 g, 5.37 mmol) in ethanol (40 ml) was refluxed with heating with hydrazine monohydrate (2.7 g) at 85° C. for 16 hours. After cooling, the solvent was evaporated, and the resulting solid was recrystallized from chloroform to give 549.2 mg of the desired product (yield 45%).

Provenance & Evidence