Cesium carbonate → HCID 24985636, compound

HRID 913404Notes

Reaction equation

HRID 913404 reaction equation
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Br[CH2:17][C:18]#[N:19].C([O-])([O-])=O.[Cs+].[Cs+]>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]#[N:19]

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 11534BromoacetonitrileHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 24985636HCID 24985636, compound

Procedure

Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, bromoacetonitrile (2 eq) and Cs2CO3 (2 eq): MS (ES) m/z 264 (M−1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-1c3dc16f1fc24fb8ac01d0f2be851a88
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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