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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913423Generated: November 1, 2026

4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile → 4-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913423

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrileHCID 24985632—
ReactantPyridine, 5-(2-bromoethoxy)-2-fluoro-HCID 67405380—
Product4-Chloro-2-(difluoromethyl)-1-{2-[(6-fluoro-3-pyridinyl)oxy]ethyl}-1H-indole-5-carbonitrileHCID 24986125—

Reaction Steps

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 5-[(2-bromoethyl)oxy]-2-fluoropyridine: MS (ESI) m/z 366 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-7f794b2105494454a803346aa77c223d
Source noteuspto-grants-2011_09