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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913428Generated: October 25, 2026

5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2-(difluoromethyl)-1H-indole-4,5-dicarbonitrile

https://huagongshe.com/reaction/913428

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-[3,5-Bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazoleHCID 2780957—
Reactant2-(difluoromethyl)-1H-indole-4,5-dicarbonitrileHCID 57800341—
Product1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2-(difluoromethyl)-1H-indole-4,5-dicarbonitrileHCID 24983680—

Reaction Steps

Synthesized as described in Example 23 from 2-(difluoromethyl)-1H-indole-4,5-dicarbonitrile and 5-[3,5-bis(trifluoromethyl)phenyl]-3-(chloromethyl)-1,2,4-oxadiazole: MS (ES) m/z 510 (M−1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-8f5a0e0a1c444dc7a4f2f87a4b828be8
Source noteuspto-grants-2011_09