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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 913445Generated: October 25, 2026

4-Methoxy-3-(trifluoromethyl)benzoyl chloride → 1-({5-[4-(Methyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/913445

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxy-3-(trifluoromethyl)benzoyl chlorideHCID 2775298—
ReactantHCID 178509476HCID 178509476—
Product1-({5-[4-(Methyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 24983992—

Reaction Steps

Synthesized as described in Example 70 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 4-(methyloxy)-3-(trifluoromethyl)benzoyl chloride. MS (ESI): m/z 467 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026262B2
Source datasetuspto-grants-2011_09
ORD IDord-5b40a01784e049dba26d82299b3cfccf
Source noteuspto-grants-2011_09