3-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole → HCID 24984459, compound

HRID 913470Notes

Reaction equation

HRID 913470 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.Cl[CH2:17][C:18]1[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[O:20][N:19]=1>>[C:23]1([C:21]2[O:20][N:19]=[C:18]([CH2:17][N:7]3[C:8]4[C:4](=[C:3]([C:2]([F:14])([F:1])[F:15])[C:11]([C:12]#[N:13])=[CH:10][CH:9]=4)[CH:5]=[CH:6]3)[N:22]=2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 3021543-(Chloromethyl)-5-phenyl-1,2,4-oxadiazoleHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 24984459HCID 24984459, compound

Procedure

Synthesized as described in Example 23 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 3-(chloromethyl)-5-phenyl-1,2,4-oxadiazole: MS (ES) m/z 369 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-d32b9e8b959746fb932a9102457cfc92
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

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