tert-Butyl bromoacetate → HCID 57800283, compound

HRID 913475Notes

Reaction equation

HRID 913475 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[C:11]([C:12]#[N:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][NH:7]2.Br[CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[C:12]([C:11]1[C:3]([C:2]([F:14])([F:1])[F:15])=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH:6]=[CH:5]2)#[N:13]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 674054494-(trifluoromethyl)-1H-indole-5-carbonitrile

Product 1

HCID 57800283HCID 57800283, compound

Procedure

Synthesized as described in Example 4 using 4-(trifluoromethyl)-1H-indole-5-carbonitrile and 1,1-dimethylethyl bromoacetate: MS (ES) m/z 325 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-e9f149df61c24ce7bd5396ea4b2984a4
Source dataset
uspto-grants-2011_09
Patent number
US08026262B2

Reaction notes

Loading…